Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 11/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 9/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KLK7 | P49862 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6878141 | 1.00 | MCHR1 (0.44) | MCHR1ADRA2ARAB9AKLK7HTR1A | |
| SCHEMBL6873592 | 0.86 | MCHR1 (0.47) | MCHR1ADRA2ARAB9AHTR1AADRA1A | |
| SCHEMBL27653069 | 0.86 | MCHR1 (0.47) | MCHR1ADRA2ARAB9AHTR1AADRA1A | |
| SCHEMBL13797488 | 0.86 | MCHR1 (0.61) | MCHR1ADRA2AHTR1AADRA1AHRH1 | |
| SCHEMBL6873300 | 0.84 | RAB9A (0.54) | MCHR1ADRA2ARAB9AKLK7HTR1A | |
| SCHEMBL6873297 | 0.84 | RAB9A (0.54) | MCHR1ADRA2ARAB9AKLK7HTR1A | |
| SCHEMBL6455845 | 0.81 | MCHR1 (0.57) | MCHR1ADRA2ARAB9AHTR1AADRA1A | |
| SCHEMBL6455852 | 0.81 | MCHR1 (0.57) | MCHR1ADRA2ARAB9AHTR1AADRA1A | |
| SCHEMBL6459641 | 0.79 | MCHR1 (0.51) | MCHR1ADRA2ARAB9AHTR1AADRA1A | |
| SCHEMBL6459623 | 0.79 | MCHR1 (0.51) | MCHR1ADRA2ARAB9AHTR1AADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |