Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 10/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 8/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ALPL | P05186 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6878204 | 1.00 | TSHR (0.45) | TSHRMCHR1EPHX1GAAADRA2A | |
| SCHEMBL6879529 | 0.89 | MCHR1 (0.43) | MCHR1ADRA2AMEN1KMT2AKDM4E | |
| SCHEMBL6879533 | 0.89 | MCHR1 (0.43) | MCHR1ADRA2AMEN1KMT2AKDM4E | |
| SCHEMBL6880619 | 0.89 | RXFP1 (0.49) | MCHR1EPHX1ADRA2AKDM4ELMNA | |
| SCHEMBL6460357 | 0.89 | EPHX1 (0.55) | MCHR1EPHX1GAAADRA2AMEN1 | |
| SCHEMBL6880627 | 0.89 | RXFP1 (0.49) | MCHR1EPHX1ADRA2AKDM4ELMNA | |
| SCHEMBL6460359 | 0.89 | EPHX1 (0.55) | MCHR1EPHX1GAAADRA2AMEN1 | |
| SCHEMBL6877686 | 0.88 | MCHR1 (0.43) | MCHR1EPHX1ADRA2AKDM4ELMNA | |
| SCHEMBL6877694 | 0.88 | MCHR1 (0.43) | MCHR1EPHX1ADRA2AKDM4ELMNA | |
| SCHEMBL6462318 | 0.88 | RAB9A (0.50) | TSHRMCHR1EPHX1ADRA2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |