Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 10/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 9/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6878237 | 1.00 | MAPT (0.40) | MAPTSMN1; SMN2LMNAGAAMEN1 | |
| SCHEMBL6878242 | 1.00 | MAPT (0.40) | MAPTSMN1; SMN2LMNAGAAMEN1 | |
| SCHEMBL6879741 | 0.93 | SMN1; SMN2 (0.39) | MAPTSMN1; SMN2LMNAGAAMEN1 | |
| SCHEMBL6879736 | 0.93 | SMN1; SMN2 (0.39) | MAPTSMN1; SMN2LMNAGAAMEN1 | |
| SCHEMBL6879728 | 0.93 | SMN1; SMN2 (0.39) | MAPTSMN1; SMN2LMNAGAAMEN1 | |
| SCHEMBL6878625 | 0.92 | SMN1; SMN2 (0.45) | MAPTSMN1; SMN2LMNAGAAMEN1 | |
| SCHEMBL6878621 | 0.92 | SMN1; SMN2 (0.45) | MAPTSMN1; SMN2LMNAGAAMEN1 | |
| SCHEMBL6876262 | 0.88 | SMN1; SMN2 (0.55) | MAPTSMN1; SMN2LMNAGAAMEN1 | |
| SCHEMBL6868208 | 0.87 | MCHR1 (0.43) | MAPTSMN1; SMN2GAAMEN1KMT2A | |
| SCHEMBL6868212 | 0.87 | MCHR1 (0.43) | MAPTSMN1; SMN2GAAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |