Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.55 |
| ▸ | ALOX12 | P18054 | 7/20 | 0.55 |
| ▸ | MAPT | P10636 | 7/20 | 0.55 |
| ▸ | LMNA | P02545 | 6/20 | 0.54 |
| ▸ | HTT | P42858 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6878625 | 0.92 | SMN1; SMN2 (0.45) | SMN1; SMN2ALOX12MAPTLMNAHTT | |
| SCHEMBL6878621 | 0.92 | SMN1; SMN2 (0.45) | SMN1; SMN2ALOX12MAPTLMNAHTT | |
| SCHEMBL6880759 | 0.90 | ALOX12 (0.43) | SMN1; SMN2ALOX12MAPTLMNAHTT | |
| SCHEMBL6880764 | 0.90 | ALOX12 (0.43) | SMN1; SMN2ALOX12MAPTLMNAHTT | |
| SCHEMBL6868231 | 0.90 | BCHE (0.46) | SMN1; SMN2ALOX12MAPTLMNAHTT | |
| SCHEMBL6868226 | 0.90 | BCHE (0.46) | SMN1; SMN2ALOX12MAPTLMNAHTT | |
| SCHEMBL6874485 | 0.89 | EPHX1 (0.54) | SMN1; SMN2ALOX12MAPTLMNAHTT | |
| SCHEMBL6874492 | 0.89 | EPHX1 (0.54) | SMN1; SMN2ALOX12MAPTLMNAHTT | |
| SCHEMBL6875537 | 0.88 | SMN1; SMN2 (0.43) | SMN1; SMN2ALOX12MAPTLMNAHTT | |
| SCHEMBL6875534 | 0.88 | SMN1; SMN2 (0.43) | SMN1; SMN2ALOX12MAPTLMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |