Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 15/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 8/20 | 0.44 |
| ▸ | HRH1 | P35367 | 4/20 | 0.42 |
| ▸ | HTR2B | P41595 | 4/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6878290 | 1.00 | MCHR1 (0.46) | MCHR1MAPK14ADRA2AHRH1HTR2B | |
| SCHEMBL6875309 | 0.88 | MCHR1 (0.47) | MCHR1MAPK14ADRA2AHRH1HTR2B | |
| SCHEMBL6875303 | 0.88 | MCHR1 (0.47) | MCHR1MAPK14ADRA2AHRH1HTR2B | |
| SCHEMBL6877476 | 0.84 | MCHR1 (0.52) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6877485 | 0.84 | MCHR1 (0.52) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6867804 | 0.82 | MCHR1 (0.49) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6867807 | 0.82 | MCHR1 (0.49) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL13793783 | 0.81 | MCHR1 (0.71) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6878847 | 0.80 | MCHR1 (0.58) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6878850 | 0.80 | MCHR1 (0.58) | MCHR1ADRA2AHRH1HTR2BADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |