Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 8/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.43 |
| ▸ | NPY5R | Q15761 | 3/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.42 |
| ▸ | HTR2B | P41595 | 2/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6875303 | 1.00 | MCHR1 (0.47) | MCHR1MAPK14ADRA2ANPY5RADRA1A | |
| SCHEMBL6878290 | 0.88 | MCHR1 (0.46) | MCHR1MAPK14ADRA2ANPY5RADRA1A | |
| SCHEMBL6878280 | 0.88 | MCHR1 (0.46) | MCHR1MAPK14ADRA2ANPY5RADRA1A | |
| SCHEMBL6458031 | 0.86 | HTR1A (0.44) | MCHR1MAPK14ADRA2AADRA1AHTR2B | |
| SCHEMBL6458026 | 0.86 | HTR1A (0.44) | MCHR1MAPK14ADRA2AADRA1AHTR2B | |
| SCHEMBL6875679 | 0.83 | MCHR1 (0.51) | MCHR1MAPK14ADRA2ANPY5RADRA1A | |
| SCHEMBL6875684 | 0.83 | MCHR1 (0.51) | MCHR1MAPK14ADRA2ANPY5RADRA1A | |
| SCHEMBL6873958 | 0.83 | HTR1A (0.47) | MCHR1MAPK14ADRA2ANPY5RHTR1A | |
| SCHEMBL6873963 | 0.83 | HTR1A (0.47) | MCHR1MAPK14ADRA2ANPY5RHTR1A | |
| SCHEMBL6880535 | 0.83 | MCHR1 (0.48) | MCHR1ADRA2ANPY5RADRA1AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |