Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 9/20 | 0.42 |
| ▸ | WDR77 | Q9BQA1 | 9/20 | 0.42 |
| ▸ | PARP1 | P09874 | 2/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6878342 | 1.00 | ALDH1A1 (0.43) | ALDH1A1PRMT5WDR77PARP1ADRA2A | |
| SCHEMBL6879219 | 0.91 | ALDH1A1 (0.55) | ALDH1A1PRMT5WDR77ADRA2AMCHR1 | |
| SCHEMBL6879216 | 0.91 | ALDH1A1 (0.55) | ALDH1A1PRMT5WDR77ADRA2AMCHR1 | |
| SCHEMBL6458047 | 0.85 | BCHE (0.43) | ALDH1A1KDM4EHRH1HTR2B | |
| SCHEMBL6872433 | 0.85 | BCHE (0.43) | ALDH1A1KDM4EHRH1HTR2B | |
| SCHEMBL6462936 | 0.83 | ALDH1A1 (0.51) | ALDH1A1ADRA2AMCHR1GAAKDM4E | |
| SCHEMBL6873997 | 0.83 | ALDH1A1 (0.51) | ALDH1A1ADRA2AMCHR1GAAKDM4E | |
| SCHEMBL13793384 | 0.83 | MCHR1 (0.55) | PRMT5WDR77ADRA2AMCHR1ADRA1A | |
| SCHEMBL6878706 | 0.81 | MCHR1 (0.46) | ALDH1A1ADRA2AMCHR1GAAKDM4E | |
| SCHEMBL6456933 | 0.81 | MCHR1 (0.46) | ALDH1A1ADRA2AMCHR1GAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |