Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 6/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.44 |
| ▸ | LMNA | P02545 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.44 |
| ▸ | USP2 | O75604 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6878414 | 1.00 | TP53 (0.44) | TP53CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL6876199 | 0.90 | MCHR1 (0.47) | TP53CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL6876191 | 0.90 | MCHR1 (0.47) | TP53CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL6873072 | 0.90 | MCHR1 (0.45) | TP53LMNAMEN1KMT2AUSP2 | |
| SCHEMBL6873067 | 0.90 | MCHR1 (0.45) | TP53LMNAMEN1KMT2AUSP2 | |
| SCHEMBL6466930 | 0.89 | MCHR1 (0.49) | LMNASIGMAR1KDM4ESMN1; SMN2MCHR1 | |
| SCHEMBL6875524 | 0.89 | MCHR1 (0.49) | LMNASIGMAR1KDM4ESMN1; SMN2MCHR1 | |
| SCHEMBL6873885 | 0.86 | MCHR1 (0.46) | TP53CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL6873877 | 0.86 | MCHR1 (0.46) | TP53CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL13793582 | 0.86 | MCHR1 (0.57) | TP53CYP1A2CYP3A4CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |