Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK3 | Q9NZJ5 | 5/20 | 0.68 |
| ▸ | TEK | Q02763 | 2/20 | 0.63 |
| ▸ | EGFR | P00533 | 2/20 | 0.59 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.59 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.59 |
| ▸ | IGF1R | P08069 | 1/20 | 0.59 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.59 |
| ▸ | PLK4 | O00444 | 1/20 | 0.52 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.52 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.52 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.52 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.52 |
| ▸ | PAK4 | O96013 | 1/20 | 0.52 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.52 |
| ▸ | ABL1 | P00519 | 1/20 | 0.52 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.52 |
| ▸ | INSR | P06213 | 1/20 | 0.52 |
| ▸ | LCK | P06239 | 1/20 | 0.52 |
| ▸ | FYN | P06241 | 1/20 | 0.52 |
| ▸ | CSF1R | P07333 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6878984 | 0.92 | TEK (0.62) | EIF2AK3TEKEGFRERBB2ERBB4 | |
| SCHEMBL2074564 | 0.90 | EIF2AK3 (0.64) | EIF2AK3TEKEGFRIGF1RABL1 | |
| SCHEMBL6465057 | 0.88 | TEK (0.65) | EIF2AK3TEKEGFRERBB2ERBB4 | |
| SCHEMBL6876636 | 0.88 | TEK (0.60) | EIF2AK3TEKEGFRERBB2ERBB4 | |
| SCHEMBL6464340 | 0.87 | EIF2AK3 (0.70) | EIF2AK3TEKEGFRERBB2ERBB4 | |
| SCHEMBL6464132 | 0.87 | TEK (0.67) | EIF2AK3TEKEGFRERBB2ERBB4 | |
| SCHEMBL6465164 | 0.87 | TEK (0.63) | EIF2AK3TEKEGFRERBB2ERBB4 | |
| SCHEMBL6459268 | 0.87 | TEK (0.65) | EIF2AK3TEKEGFRERBB2ERBB4 | |
| Benzenesulfonamide SCHEMBL6885520 | 0.87 | TEK (0.65) | EIF2AK3TEKEGFRERBB2ERBB4 | |
| SCHEMBL6462003 | 0.87 | TEK (0.68) | EIF2AK3TEKEGFRERBB2ERBB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004100868-A2 | METHOD OF TREATING TRANSPLANT REJECTION | ABBOTT LABORATORIES (US) | 2004-11-25 | — | — | WO | disclosed |
| WO-2001072751-A1 | PYRROLOPYRIMIDINES AS TYROSINE KINASE INHIBITORS | KNOLL GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2001-10-04 | — | — | WO | disclosed |