Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | APP | P05067 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | BCHE | P06276 | 2/20 | 0.42 |
| ▸ | ACHE | P22303 | 2/20 | 0.42 |
| ▸ | CTSD | P07339 | 7/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6878654 | 1.00 | SIGMAR1 (0.47) | SIGMAR1APPALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL6878087 | 0.91 | SIGMAR1 (0.47) | SIGMAR1APPALDH1A1MAPK1ADRA2A | |
| SCHEMBL6878081 | 0.91 | SIGMAR1 (0.47) | SIGMAR1APPALDH1A1MAPK1ADRA2A | |
| SCHEMBL6456953 | 0.91 | MCHR1 (0.41) | SIGMAR1APPSMN1; SMN2ADRA2AMCHR1 | |
| SCHEMBL6456938 | 0.91 | MCHR1 (0.41) | SIGMAR1APPSMN1; SMN2ADRA2AMCHR1 | |
| SCHEMBL6457880 | 0.88 | EPHX2 (0.55) | SIGMAR1APPALDH1A1SMN1; SMN2ADRA2A | |
| SCHEMBL6457869 | 0.88 | EPHX2 (0.55) | SIGMAR1APPALDH1A1SMN1; SMN2ADRA2A | |
| SCHEMBL6456764 | 0.88 | POLB (0.48) | SIGMAR1ALDH1A1SMN1; SMN2ADRA2AMCHR1 | |
| SCHEMBL6456777 | 0.88 | POLB (0.48) | SIGMAR1ALDH1A1SMN1; SMN2ADRA2AMCHR1 | |
| SCHEMBL6876352 | 0.87 | MCHR1 (0.50) | SIGMAR1APPADRA2AMCHR1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |