Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.34 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL686857 | 0.96 | SMN1; SMN2 (0.41) | KMT2AMEN1SMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL687765 | 0.93 | KMT2A (0.37) | KMT2AMEN1SMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL688680 | 0.92 | MEN1 (0.41) | KMT2AMEN1SMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL686816 | 0.92 | MEN1 (0.38) | KMT2AMEN1SMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL688605 | 0.91 | MEN1 (0.41) | KMT2AMEN1SMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL688336 | 0.90 | HPGD (0.38) | KMT2AMEN1SMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL687500 | 0.90 | SMN1; SMN2 (0.37) | KMT2AMEN1SMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL688345 | 0.88 | MEN1 (0.41) | KMT2AMEN1SMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL688052 | 0.88 | MEN1 (0.44) | KMT2AMEN1SMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL686968 | 0.88 | MEN1 (0.38) | KMT2AMEN1SMN1; SMN2HPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1203766-B1 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS INC (US) | 2012-02-29 | — | — | EP | disclosed |
| EP-1203766-A2 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2002-05-08 | — | — | EP | disclosed |