Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6878955 | 1.00 | MCHR1 (0.43) | MCHR1SMN1; SMN2LMNAKDM4EMAPT | |
| SCHEMBL6867611 | 0.90 | SMN1; SMN2 (0.47) | MCHR1SMN1; SMN2LMNAKDM4EMAPT | |
| SCHEMBL6867605 | 0.90 | SMN1; SMN2 (0.47) | MCHR1SMN1; SMN2LMNAKDM4EMAPT | |
| SCHEMBL6868161 | 0.88 | MCHR1 (0.45) | MCHR1SMN1; SMN2LMNAKDM4EMAPT | |
| SCHEMBL6868153 | 0.88 | MCHR1 (0.45) | MCHR1SMN1; SMN2LMNAKDM4EMAPT | |
| SCHEMBL6874633 | 0.85 | MAPT (0.49) | MCHR1SMN1; SMN2LMNAKDM4EMAPT | |
| SCHEMBL6874644 | 0.85 | MAPT (0.49) | MCHR1SMN1; SMN2LMNAKDM4EMAPT | |
| SCHEMBL6874938 | 0.84 | EGFR (0.54) | MCHR1SMN1; SMN2LMNAMAPTGAA | |
| SCHEMBL6874955 | 0.84 | EGFR (0.54) | MCHR1SMN1; SMN2LMNAMAPTGAA | |
| SCHEMBL6874434 | 0.84 | EGFR (0.47) | MCHR1SMN1; SMN2LMNAKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |