Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | APP | P05067 | 2/20 | 0.41 |
| ▸ | BCHE | P06276 | 2/20 | 0.41 |
| ▸ | ACHE | P22303 | 2/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6874633 | 1.00 | MAPT (0.49) | MAPTSMN1; SMN2APPBCHEACHE | |
| SCHEMBL6463160 | 0.91 | MCHR1 (0.43) | MAPTSMN1; SMN2MCHR1ADRA2ALMNA | |
| SCHEMBL6463137 | 0.91 | MCHR1 (0.43) | MAPTSMN1; SMN2MCHR1ADRA2ALMNA | |
| SCHEMBL6880545 | 0.89 | MAPT (0.54) | MAPTSMN1; SMN2APPBCHEACHE | |
| SCHEMBL6880550 | 0.89 | MAPT (0.54) | MAPTSMN1; SMN2APPBCHEACHE | |
| SCHEMBL6872176 | 0.87 | LMNA (0.53) | MAPTSMN1; SMN2MCHR1ADRA2AALDH1A1 | |
| SCHEMBL6872189 | 0.87 | LMNA (0.53) | MAPTSMN1; SMN2MCHR1ADRA2AALDH1A1 | |
| SCHEMBL6874756 | 0.86 | LMNA (0.43) | SMN1; SMN2MCHR1ADRA2AALDH1A1LMNA | |
| SCHEMBL6874763 | 0.86 | LMNA (0.43) | SMN1; SMN2MCHR1ADRA2AALDH1A1LMNA | |
| SCHEMBL6867611 | 0.85 | SMN1; SMN2 (0.47) | MAPTSMN1; SMN2BCHEACHEMCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |