Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 7/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 6/20 | 0.40 |
| ▸ | NPY5R | Q15761 | 3/20 | 0.40 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 3/20 | 0.36 |
| ▸ | DRD4 | P21917 | 3/20 | 0.36 |
| ▸ | DRD3 | P35462 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6878985 | 1.00 | MCHR1 (0.45) | MCHR1LMNAKDM4ESMN1; SMN2ADRA2A | |
| SCHEMBL6878808 | 0.87 | MCHR1 (0.48) | MCHR1LMNAKDM4ESMN1; SMN2ADRA2A | |
| SCHEMBL6878811 | 0.87 | MCHR1 (0.48) | MCHR1LMNAKDM4ESMN1; SMN2ADRA2A | |
| SCHEMBL6880757 | 0.87 | MCHR1 (0.48) | MCHR1LMNAKDM4ESMN1; SMN2ADRA2A | |
| SCHEMBL6880754 | 0.87 | MCHR1 (0.48) | MCHR1LMNAKDM4ESMN1; SMN2ADRA2A | |
| SCHEMBL6874150 | 0.85 | MCHR1 (0.44) | MCHR1LMNAADRA2AKMT2ATP53 | |
| SCHEMBL6874146 | 0.85 | MCHR1 (0.44) | MCHR1LMNAADRA2AKMT2ATP53 | |
| SCHEMBL6879235 | 0.84 | MCHR1 (0.43) | MCHR1LMNAKDM4ESMN1; SMN2ADRA2A | |
| SCHEMBL6874823 | 0.82 | CNR2 (0.48) | MCHR1LMNASMN1; SMN2ADRA2AMEN1 | |
| SCHEMBL6874816 | 0.82 | CNR2 (0.48) | MCHR1LMNASMN1; SMN2ADRA2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |