Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.49 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 7/20 | 0.49 |
| ▸ | TP53 | P04637 | 4/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | CCKBR | P32239 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6879057 | 1.00 | GSK3B (0.49) | GSK3BCSNK2A1MAPTTP53MAPK1 | |
| SCHEMBL6869115 | 0.92 | MAPT (0.48) | MAPTTP53MAPK1TSHRSMN1; SMN2 | |
| SCHEMBL6869121 | 0.92 | MAPT (0.48) | MAPTTP53MAPK1TSHRSMN1; SMN2 | |
| SCHEMBL4036980 | 0.85 | MCHR1 (0.62) | GSK3BCSNK2A1MAPTTP53NPC1 | |
| SCHEMBL4036978 | 0.85 | MCHR1 (0.62) | GSK3BCSNK2A1MAPTTP53NPC1 | |
| SCHEMBL6872848 | 0.83 | NPC1 (0.46) | MAPTNPC1ALDH1A1RAB9AMEN1 | |
| SCHEMBL6872842 | 0.83 | NPC1 (0.46) | MAPTNPC1ALDH1A1RAB9AMEN1 | |
| SCHEMBL6457991 | 0.81 | EPHX1 (0.47) | TP53SMN1; SMN2KMT2ALMNA | |
| SCHEMBL6457984 | 0.81 | EPHX1 (0.47) | TP53SMN1; SMN2KMT2ALMNA | |
| SCHEMBL6877850 | 0.81 | EPHX1 (0.49) | TP53SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |