Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.48 |
| ▸ | TP53 | P04637 | 4/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | NPY2R | P49146 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6869115 | 1.00 | MAPT (0.48) | MAPTTP53MAPK1LMNAALDH1A1 | |
| SCHEMBL6879063 | 0.92 | GSK3B (0.49) | MAPTTP53MAPK1LMNAALDH1A1 | |
| SCHEMBL6879057 | 0.92 | GSK3B (0.49) | MAPTTP53MAPK1LMNAALDH1A1 | |
| SCHEMBL6872848 | 0.92 | NPC1 (0.46) | MAPTLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL6872842 | 0.92 | NPC1 (0.46) | MAPTLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL4040823 | 0.86 | MCHR1 (0.61) | MAPTTP53MAPK1LMNAALDH1A1 | |
| SCHEMBL5530177 | 0.86 | MCHR1 (0.61) | MAPTTP53MAPK1LMNAALDH1A1 | |
| SCHEMBL6463465 | 0.81 | MCHR1 (0.44) | TP53LMNASMN1; SMN2HTTADRA2A | |
| SCHEMBL6463450 | 0.81 | MCHR1 (0.44) | TP53LMNASMN1; SMN2HTTADRA2A | |
| SCHEMBL6878768 | 0.79 | ALDH1A1 (0.45) | MAPTTP53MAPK1LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |