Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.38 |
| ▸ | KAT6A | Q92794 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.36 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.36 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.36 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.35 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | TNIK | Q9UKE5 | 3/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6879086 | 1.00 | KDM4E (0.39) | KDM4EALDH1A1MAPK1NOTUMPDK2 | |
| SCHEMBL6879079 | 1.00 | KDM4E (0.39) | KDM4EALDH1A1MAPK1NOTUMPDK2 | |
| SCHEMBL6852518 | 0.80 | KDM4E (0.40) | KDM4EALDH1A1MAPK1NOTUMPDK2 | |
| SCHEMBL6852516 | 0.80 | KDM4E (0.40) | KDM4EALDH1A1MAPK1NOTUMPDK2 | |
| SCHEMBL6852346 | 0.79 | KDM4E (0.55) | KDM4EALDH1A1MAPK1NOTUMPDK2 | |
| SCHEMBL6852339 | 0.79 | KDM4E (0.55) | KDM4EALDH1A1MAPK1NOTUMPDK2 | |
| SCHEMBL6852332 | 0.79 | KDM4E (0.55) | KDM4EALDH1A1MAPK1NOTUMPDK2 | |
| SCHEMBL6850771 | 0.77 | KDM4E (0.57) | KDM4EALDH1A1MAPK1NOTUMPDK2 | |
| SCHEMBL27402020 | 0.77 | MAPK1 (0.45) | KDM4EALDH1A1MAPK1NOTUMPDK2 | |
| SCHEMBL18172304 | 0.77 | KDM4E (0.42) | KDM4EALDH1A1MAPK1NOTUMPDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6825170-B2 | ERYTHROMYCIN TYPE MACROLIDE WITH A FUSED OXAZOLONE RING | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2004-11-30 | — | — | US | disclosed |