Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 6/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.42 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.37 |
| ▸ | HTR2B | P41595 | 2/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 3/20 | 0.35 |
| ▸ | BCHE | P06276 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6463847 | 1.00 | MCHR1 (0.42) | MCHR1ADRA2ANPY5RCNR1KCNH2 | |
| SCHEMBL6877742 | 0.91 | ALDH1A1 (0.45) | MCHR1ADRA2ANPY5RTSHRALDH1A1 | |
| SCHEMBL6877746 | 0.91 | ALDH1A1 (0.45) | MCHR1ADRA2ANPY5RTSHRALDH1A1 | |
| SCHEMBL6877060 | 0.89 | MCHR1 (0.41) | MCHR1ADRA2ANPY5RKCNH2ALDH1A1 | |
| SCHEMBL6875712 | 0.89 | MCHR1 (0.41) | MCHR1ADRA2ANPY5RCNR1KCNH2 | |
| SCHEMBL6876919 | 0.89 | MCHR1 (0.41) | MCHR1ADRA2ANPY5RADRA1AHTR2B | |
| SCHEMBL6877050 | 0.89 | MCHR1 (0.41) | MCHR1ADRA2ANPY5RKCNH2ALDH1A1 | |
| SCHEMBL6876906 | 0.89 | MCHR1 (0.41) | MCHR1ADRA2ANPY5RADRA1AHTR2B | |
| SCHEMBL6875706 | 0.89 | MCHR1 (0.41) | MCHR1ADRA2ANPY5RCNR1KCNH2 | |
| SCHEMBL6462936 | 0.88 | ALDH1A1 (0.51) | MCHR1ADRA2ACNR1KCNH2AURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |