Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | FDFT1 | P37268 | 1/20 | 0.34 |
| ▸ | IGF1R | P08069 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | LIPG | Q9Y5X9 | 3/20 | 0.32 |
| ▸ | LIPC | P11150 | 2/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
| ▸ | PYGL | P06737 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6078367 | 1.00 | CDK8 (0.36) | CDK8CLK4PDPK1TSHRFDFT1 | |
| SCHEMBL6077836 | 0.88 | TSHR (0.37) | PDPK1TSHRHIF1AMAPTMEN1 | |
| SCHEMBL6077496 | 0.88 | TSHR (0.37) | PDPK1TSHRHIF1AMAPTMEN1 | |
| SCHEMBL6076726 | 0.87 | CDK8 (0.38) | CDK8CLK4PDPK1TSHRIGF1R | |
| SCHEMBL6448437 | 0.85 | ALDH1A1 (0.35) | TSHRCHRM5CHRM1CHRM3ALDH1A1 | |
| SCHEMBL6077698 | 0.85 | ALDH1A1 (0.35) | TSHRCHRM5CHRM1CHRM3ALDH1A1 | |
| SCHEMBL6077362 | 0.82 | TRPV1 (0.41) | PDPK1LIPGTRPV1SIGMAR1 | |
| SCHEMBL6077360 | 0.82 | TRPV1 (0.41) | PDPK1LIPGTRPV1SIGMAR1 | |
| SCHEMBL6417430 | 0.79 | POLB (0.38) | PDPK1MAPTMEN1ALDH1A1TP53 | |
| SCHEMBL6417431 | 0.79 | POLB (0.38) | PDPK1MAPTMEN1ALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6777440-B2 | HIV integrase inhibitors | BRISTOL-MYERS SQUIBB COMPANY | 2004-08-17 | — | — | US | disclosed |
| US-20030176495-A1 | HIV Integrase inhibitors | BRISTOL-MYERS SQUIBB COMPANY | 2003-09-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030176495-A1 | HIV Integrase inhibitors | MAPT, RIF1, HPRT1 | CDK8 40/4885CLK4 2831/4885PDPK1 1267/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.