Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 6/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6879424 | 1.00 | MCHR1 (0.46) | MCHR1ACHEBACE1MAPK1NPC1 | |
| SCHEMBL6872390 | 0.90 | ACHE (0.46) | MCHR1ACHEBACE1MAPK1NPC1 | |
| SCHEMBL6875685 | 0.86 | MAPK14 (0.50) | MCHR1MAPK1NPC1RAB9AKMT2A | |
| SCHEMBL6875689 | 0.86 | MAPK14 (0.50) | MCHR1MAPK1NPC1RAB9AKMT2A | |
| SCHEMBL6458463 | 0.85 | MCHR1 (0.47) | MCHR1NPC1RAB9AMAPK14ADRA2A | |
| SCHEMBL6458476 | 0.85 | MCHR1 (0.47) | MCHR1NPC1RAB9AMAPK14ADRA2A | |
| SCHEMBL6867719 | 0.83 | MCHR1 (0.53) | MCHR1MAPK14ADRA2AADRA1AHRH1 | |
| SCHEMBL6867713 | 0.83 | MCHR1 (0.53) | MCHR1MAPK14ADRA2AADRA1AHRH1 | |
| SCHEMBL6460500 | 0.83 | MCHR1 (0.45) | MCHR1MAPK1RAB9AMEN1TP53 | |
| SCHEMBL6460506 | 0.83 | MCHR1 (0.45) | MCHR1MAPK1RAB9AMEN1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |