Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 2/20 | 0.56 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.42 |
| ▸ | MERTK | Q12866 | 2/20 | 0.42 |
| ▸ | GAS6 | Q14393 | 2/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.38 |
| ▸ | HRH1 | P35367 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6879538 | 1.00 | EPHX1 (0.56) | EPHX1EPHX2NPC1RAB9ATP53 | |
| SCHEMBL6879296 | 0.91 | NPC1 (0.55) | EPHX1EPHX2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6879303 | 0.91 | NPC1 (0.55) | EPHX1EPHX2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6876167 | 0.90 | NPC1 (0.47) | EPHX1EPHX2NPC1RAB9ATP53 | |
| SCHEMBL6876164 | 0.90 | NPC1 (0.47) | EPHX1EPHX2NPC1RAB9ATP53 | |
| SCHEMBL6867882 | 0.89 | KDM4E (0.46) | EPHX1EPHX2NPC1RAB9ATP53 | |
| SCHEMBL6867886 | 0.89 | KDM4E (0.46) | EPHX1EPHX2NPC1RAB9ATP53 | |
| SCHEMBL6876601 | 0.88 | EPHX2 (0.46) | EPHX1EPHX2NPC1RAB9ATP53 | |
| SCHEMBL6878079 | 0.88 | EPHX2 (0.41) | EPHX1EPHX2TYRO3MERTKGAS6 | |
| SCHEMBL6876610 | 0.88 | EPHX2 (0.46) | EPHX1EPHX2NPC1RAB9ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |