Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | CHKA | P35790 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 2/20 | 0.31 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.31 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.31 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.31 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.31 |
| ▸ | ITGAV | P06756 | 1/20 | 0.31 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.30 |
| ▸ | STAT3 | P40763 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6873497 | 0.93 | ITGB3 (0.36) | MAPTKMT2ACHKAMEN1THRB | |
| SCHEMBL6881802 | 0.92 | ITGB3 (0.36) | MAPTKMT2AMEN1THRBSIRT2 | |
| Benzene SCHEMBL6882109 | 0.91 | MAPT (0.35) | MAPTKMT2AMEN1THRBITGB3 | |
| SCHEMBL6879633 | 0.91 | ITGB3 (0.35) | MAPTKMT2AMEN1ITGB3ITGAV | |
| SCHEMBL6882858 | 0.90 | CHKA (0.34) | MAPTKMT2ACHKAMEN1THRB | |
| SCHEMBL6882095 | 0.90 | STS (0.41) | MAPTKMT2AMEN1ITGB3ITGAV | |
| SCHEMBL6884349 | 0.88 | ITGB3 (0.37) | MAPTKMT2AITGB3ITGAVITGA2B | |
| SCHEMBL6880260 | 0.87 | ITGB3 (0.39) | MAPTKMT2AITGB3ITGAVITGA2B | |
| SCHEMBL6873951 | 0.87 | ITGB3 (0.41) | MAPTCHKAITGB3ITGAVITGA2B | |
| SCHEMBL6881852 | 0.86 | ITGB3 (0.38) | MAPTKMT2AMEN1ITGB3ITGAV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6747016-B1 | TREATING OSTEOPOROSIS IN WARM-BLOODED ANIMALS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2004-06-08 | — | — | US | disclosed |
| EP-1196416-B1 | SUBSTITUTED PURINE DERIVATIVES AS INHIBITORS OF CELL ADHESION | AVENTIS PHARMA GMBH (DE) | 2004-03-24 | — | — | EP | disclosed |
| EP-1196416-A1 | SUBSTITUTED PURINE DERIVATIVES AS INHIBITORS OF CELL ADHESION | Aventis Pharma Deutschland GmbH (DE) | 2002-04-17 | — | — | EP | disclosed |
| WO-2001002399-A1 | SUBSTITUTED PURINE DERIVATIVES AS INHIBITORS OF CELL ADHESION | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2001-01-11 | — | — | WO | disclosed |
| EP-1065208-A1 | Substituted purine derivatives as inhibitors of cell adhesion | Aventis Pharma Deutschland GmbH (DE) | 2001-01-03 | — | — | EP | disclosed |