Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.55 |
| ▸ | LMNA | P02545 | 5/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | TSHR | P16473 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL6881965 | 0.99 | ALDH1A1 (0.54) | ALDH1A1LMNAHPGDTSHRSMN1; SMN2 | |
| Bicarbonate SCHEMBL6881104 | 0.96 | ALDH1A1 (0.54) | ALDH1A1LMNAHPGDTSHRSMN1; SMN2 | |
| SCHEMBL6881406 | 0.95 | ALDH1A1 (0.55) | ALDH1A1LMNAHPGDTSHRSMN1; SMN2 | |
| SCHEMBL6882995 | 0.94 | ALDH1A1 (0.55) | ALDH1A1LMNAHPGDTSHRSMN1; SMN2 | |
| SCHEMBL6882777 | 0.94 | ALDH1A1 (0.55) | ALDH1A1LMNAHPGDTSHRSMN1; SMN2 | |
| SCHEMBL6880175 | 0.93 | ALDH1A1 (0.53) | ALDH1A1LMNAHPGDTSHRSMN1; SMN2 | |
| SCHEMBL6874203 | 0.91 | ALDH1A1 (0.53) | ALDH1A1LMNAHPGDTSHRSMN1; SMN2 | |
| Bicarbonate SCHEMBL6881098 | 0.82 | ALDH1A1 (0.59) | ALDH1A1LMNAHPGDTSHRSMN1; SMN2 | |
| SCHEMBL6879937 | 0.77 | ALDH1A1 (0.59) | ALDH1A1LMNAHPGDTSHRSMN1; SMN2 | |
| SCHEMBL6778063 | 0.77 | KDM4E (0.44) | ALDH1A1SMN1; SMN2KDM4EKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1210326-B1 | HYDROXAMIC ACID COMPOUNDS USEFUL AS MATRIX METALLOPROTEINASE INHIBITORS | WARNER LAMBERT CO (US) | 2004-02-25 | — | — | EP | claimed |