Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 12/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 10/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.42 |
| ▸ | CDK2 | P24941 | 2/20 | 0.42 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6879837 | 1.00 | MCHR1 (0.44) | MCHR1ADRA2ACCNA2CDK2CCNA1 | |
| SCHEMBL6878095 | 0.91 | TSHR (0.55) | MCHR1ADRA2ATSHRSMN1; SMN2KDM4E | |
| SCHEMBL6878098 | 0.91 | TSHR (0.55) | MCHR1ADRA2ATSHRSMN1; SMN2KDM4E | |
| SCHEMBL6460716 | 0.88 | MCHR1 (0.46) | MCHR1ADRA2ASMN1; SMN2KDM4ELMNA | |
| SCHEMBL6460722 | 0.88 | MCHR1 (0.46) | MCHR1ADRA2ASMN1; SMN2KDM4ELMNA | |
| SCHEMBL6873947 | 0.85 | MCHR1 (0.47) | MCHR1ADRA2ASMN1; SMN2KDM4ELMNA | |
| SCHEMBL6873948 | 0.85 | MCHR1 (0.47) | MCHR1ADRA2ASMN1; SMN2KDM4ELMNA | |
| SCHEMBL6874583 | 0.83 | LMNA (0.52) | MCHR1ADRA2ASMN1; SMN2KDM4ELMNA | |
| SCHEMBL6874577 | 0.83 | LMNA (0.52) | MCHR1ADRA2ASMN1; SMN2KDM4ELMNA | |
| SCHEMBL6873538 | 0.83 | MCHR1 (0.48) | MCHR1ADRA2ASMN1; SMN2KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |