Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 11/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL687825 | 0.95 | NR1H4 (0.53) | NR1H4ALDH1A1HPGDELANEMAPT | |
| SCHEMBL275401 | 0.86 | NR1H4 (0.72) | NR1H4ALDH1A1HPGDELANEMAPT | |
| SCHEMBL689096 | 0.85 | CYP3A4 (0.45) | NR1H4ALDH1A1HPGDELANEMAPT | |
| SCHEMBL274819 | 0.83 | NR1H4 (0.70) | NR1H4ALDH1A1HPGDELANEMAPT | |
| SCHEMBL274043 | 0.81 | NR1H4 (0.72) | NR1H4ALDH1A1HPGDELANEMAPT | |
| SCHEMBL275693 | 0.78 | NR1H4 (0.70) | NR1H4ALDH1A1HPGDMAPTKMT2A | |
| SCHEMBL274013 | 0.77 | NR1H4 (0.73) | NR1H4ALDH1A1HPGDELANEMAPT | |
| SCHEMBL688979 | 0.74 | NR1H4 (0.47) | NR1H4ALDH1A1HPGDMAPTKMT2A | |
| SCHEMBL274076 | 0.74 | NR1H4 (0.52) | NR1H4ALDH1A1HPGDMAPTKMT2A | |
| SCHEMBL687797 | 0.74 | NR1H4 (0.46) | NR1H4ALDH1A1HPGDMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1532153-B1 | AZEPINOINDOLE AND PYRIDOINDOLE DERIVATIVES AS PHARMACEUTICAL AGENTS | X CEPTOR THERAPEUTICS INC (US) | 2012-02-29 | — | — | EP | claimed |