Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | CDC7 | O00311 | 3/20 | 0.41 |
| ▸ | DBF4 | Q9UBU7 | 3/20 | 0.41 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL715227 | 0.87 | CDC7 (0.43) | NR1H4CDC7DBF4NPC1SMN1; SMN2 | |
| SCHEMBL273588 | 0.87 | NR1H4 (0.62) | NR1H4CNR1CDC7DBF4TRPM8 | |
| SCHEMBL688979 | 0.86 | NR1H4 (0.47) | NR1H4ALOX5HPGDNPC1SMN1; SMN2 | |
| SCHEMBL688779 | 0.78 | NR1H4 (0.45) | NR1H4ALDH1A1MAPTKMT2AAURKA | |
| SCHEMBL275094 | 0.74 | NR1H4 (0.57) | NR1H4CDC7DBF4NPC1ALDH1A1 | |
| SCHEMBL274417 | 0.74 | NR1H4 (0.62) | NR1H4HPGDNPC1ALDH1A1MAPT | |
| SCHEMBL687997 | 0.74 | NR1H4 (0.53) | NR1H4HPGDNPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL687825 | 0.74 | NR1H4 (0.53) | NR1H4HPGDNPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL274293 | 0.69 | NR1H4 (0.65) | NR1H4HPGDALDH1A1MAPTKMT2A | |
| SCHEMBL688726 | 0.69 | BAZ2B (0.40) | NR1H4HPGDNPC1SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1532153-B1 | AZEPINOINDOLE AND PYRIDOINDOLE DERIVATIVES AS PHARMACEUTICAL AGENTS | X CEPTOR THERAPEUTICS INC (US) | 2012-02-29 | — | — | EP | claimed |