Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.43 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.43 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.43 |
| ▸ | ELANE | P08246 | 1/20 | 0.42 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.42 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.42 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.42 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.42 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.42 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16256993 | 0.88 | AGTR2 (0.51) | HTR2CPOLBPDK1PDK2PDK3 | |
| SCHEMBL16648040 | 0.86 | HTR2C (0.46) | HTR2CPOLBPDK1PDK2PDK3 | |
| SCHEMBL16635923 | 0.86 | HTR2C (0.46) | HTR2CPOLBPDK1PDK2PDK3 | |
| SCHEMBL15701442 | 0.83 | HTR2C (0.44) | HTR2CPOLBAGTR2ELANETSHR | |
| SCHEMBL12011239 | 0.83 | HTR2C (0.44) | HTR2CPOLBAGTR2ELANETSHR | |
| SCHEMBL13318714 | 0.83 | HTR2C (0.44) | HTR2CPOLBAGTR2ELANETSHR | |
| SCHEMBL18286548 | 0.82 | POLB (0.45) | HTR2CPOLBPDK1PDK2PDK3 | |
| SCHEMBL16648015 | 0.82 | HTR2C (0.45) | HTR2CPOLBPDK1PDK2PDK3 | |
| SCHEMBL38660463 | 0.82 | ELANE (0.50) | HTR2CELANETSHRL3MBTL1KDM4E | |
| SCHEMBL6882618 | 0.82 | ELANE (0.50) | HTR2CELANETSHRL3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011091407-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLP (US) | 2011-07-28 | — | — | WO | disclosed |