Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOX4 | Q9NPH5 | 20/20 | 1.00 |
| ▸ | CYBB | P04839 | 19/20 | 1.00 |
| ▸ | NOX5 | Q96PH1 | 19/20 | 1.00 |
| ▸ | NOX1 | Q9Y5S8 | 19/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1565623 | 0.79 | CYBB (1.00) | NOX4CYBBNOX5NOX1 | |
| SCHEMBL1460392 | 0.76 | CYBB (1.00) | NOX4CYBBNOX5NOX1 | |
| SCHEMBL19210793 | 0.75 | CYBB (0.75) | NOX4CYBBNOX5NOX1 | |
| SCHEMBL1566689 | 0.75 | CYBB (1.00) | NOX4CYBBNOX5NOX1 | |
| SCHEMBL1566481 | 0.75 | CYBB (1.00) | NOX4CYBBNOX5NOX1 | |
| SCHEMBL1565877 | 0.74 | CYBB (1.00) | NOX4CYBBNOX5NOX1 | |
| SCHEMBL2216063 | 0.73 | NOX4 (0.60) | NOX4CYBBNOX5NOX1 | |
| SCHEMBL1566429 | 0.72 | CYBB (1.00) | NOX4CYBBNOX5NOX1 | |
| SCHEMBL1303388 | 0.72 | NOX4 (0.65) | NOX4CYBBNOX5NOX1 | |
| SCHEMBL1302610 | 0.72 | NOX4 (0.81) | NOX4CYBBNOX5NOX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483271-B1 | PYRAZOLINE DIONE DERIVATIVES AS NADPH OXIDASE INHIBITORS | GENKYOTEX SUISSE SA (CH) | 2017-08-16 | — | — | EP | claimed |
| EP-2483271-B1 | PYRAZOLINE DIONE DERIVATIVES AS NADPH OXIDASE INHIBITORS | GENKYOTEX SUISSE SA (CH) | 2017-08-16 | — | — | EP | disclosed |
| EP-2483271-B1 | PYRAZOLINE DIONE DERIVATIVES AS NADPH OXIDASE INHIBITORS | GENKYOTEX SUISSE SA (CH) | 2017-08-16 | — | — | EP | disclosed |
| US-9394306-B2 | Pyrazoline dione derivatives as NADPH oxidase inhibitors | GENKYOTEX SA (CH) | 2016-07-19 | — | — | US | disclosed |
| US-9394306-B2 | Pyrazoline dione derivatives as NADPH oxidase inhibitors | GENKYOTEX SA (CH) | 2016-07-19 | — | — | US | disclosed |
| US-9394306-B2 | Pyrazoline dione derivatives as NADPH oxidase inhibitors | GENKYOTEX SA (CH) | 2016-07-19 | — | — | US | disclosed |
| US-20120172352-A1 | PYRAZOLINE DIONE DERIVATIVES AS NADPH OXIDASE INHIBITORS | GENKYOTEX SA (CH) | 2012-07-05 | — | — | US | disclosed |
| US-20120172352-A1 | PYRAZOLINE DIONE DERIVATIVES AS NADPH OXIDASE INHIBITORS | GENKYOTEX SA (CH) | 2012-07-05 | — | — | US | disclosed |
| EP-2305679-A1 | Pyrazoline dione derivatives as nadph oxidase inhibitors | GenKyoTex SA (CH) | 2011-04-06 | — | — | EP | disclosed |
| WO-2011036651-A1 | PYRAZOLINE DIONE DERIVATIVES AS NADPH OXIDASE INHIBITORS | GENKYOTEX SA (CH) | 2011-03-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120172352-A1 | PYRAZOLINE DIONE DERIVATIVES AS NADPH OXIDASE INHIBITORS | NOX1, NOX5, CYBB | NOX4 4/4885CYBB 3/4885NOX5 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.