Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.34 |
| ▸ | APP | P05067 | 4/20 | 0.34 |
| ▸ | SNCA | P37840 | 4/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.32 |
| ▸ | METAP2 | P50579 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.30 |
| ▸ | AURKA | O14965 | 1/20 | 0.30 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.30 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5873791 | 0.79 | MAPT (0.40) | MAPTAPPSNCAGAAALDH1A1 | |
| SCHEMBL5873788 | 0.79 | MAPT (0.40) | MAPTAPPSNCAGAAALDH1A1 | |
| SCHEMBL7661382 | 0.76 | TRPV1 (0.44) | MAPTALDH1A1MCL1CYP2C9CYP2C19 | |
| SCHEMBL5873955 | 0.75 | KMT2A (0.39) | MAPTGAAALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL6872495 | 0.75 | KMT2A (0.39) | MAPTGAAALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL7704854 | 0.72 | CCNT1 (0.40) | MAPTAPPSNCAALDH1A1CDK9 | |
| SCHEMBL5430107 | 0.71 | CYP1A2 (0.33) | MAPTCYP2C9CYP2C19CYP1A2HPGD | |
| SCHEMBL5430111 | 0.71 | CYP1A2 (0.33) | MAPTCYP2C9CYP2C19CYP1A2HPGD | |
| SCHEMBL6880716 | 0.70 | NTRK1 (0.39) | MAPTAPPALDH1A1NTRK1FLT3 | |
| SCHEMBL6880710 | 0.70 | NTRK1 (0.39) | MAPTAPPALDH1A1NTRK1FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6818632-B2 | 3-(anilinomethylene)oxindoles | SMITHKLINE BEECHAM CORPORATION | 2004-11-16 | — | — | US | disclosed |
| EP-1165514-A1 | 3-(ANILINOMETHYLENE) OXINDOLES AS PROTEIN TYROSINE KINASE AND PROTEIN SERINE/THREONINE KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000056710-A1 | 3-(ANILINOMETHYLENE) OXINDOLES AS PROTEIN TYROSINE KINASE AND PROTEIN SERINE/THREONINE KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2000-09-28 | — | — | WO | disclosed |