Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 3/20 | 0.40 |
| ▸ | CDK9 | P50750 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | APP | P05067 | 4/20 | 0.38 |
| ▸ | SNCA | P37840 | 4/20 | 0.38 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.37 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5873841 | 0.79 | CCNT1 (0.41) | CCNT1CDK9MAPTAPPSNCA | |
| SCHEMBL5873837 | 0.79 | CCNT1 (0.41) | CCNT1CDK9MAPTAPPSNCA | |
| SCHEMBL5873933 | 0.75 | CCNT1 (0.39) | CCNT1CDK9MAPTPTK2NPY5R | |
| SCHEMBL5873934 | 0.75 | CCNT1 (0.39) | CCNT1CDK9MAPTPTK2NPY5R | |
| SCHEMBL7661382 | 0.72 | TRPV1 (0.44) | MAPTKMT2AALDH1A1KDM4EHTT | |
| SCHEMBL6880694 | 0.72 | MAPT (0.34) | CDK9MAPTAPPSNCAPTK2 | |
| SCHEMBL7699449 | 0.71 | RXFP1 (0.40) | MAPTAPPSNCAALDH1A1TP53 | |
| SCHEMBL5873716 | 0.69 | NTRK1 (0.40) | CCNT1CDK9PTK2NPY5RBTK | |
| SCHEMBL5873720 | 0.69 | NTRK1 (0.40) | CCNT1CDK9PTK2NPY5RBTK | |
| SCHEMBL6872584 | 0.69 | CDK9 (0.40) | CCNT1CDK9PTK2NPY5RBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6350747-B1 | PROTEIN SERINE/THREONINE KINASE AND PROTEIN TYROSINE KINASE ENZYME INHIBITORS; ANGIOGENESIS INHIBITORS; ANTITUMOR AND ANTIPROLIFERATIVE AGENTS | GLAXO WELLCOME INC. | 2002-02-26 | — | — | US | disclosed |