Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 13/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 6/20 | 0.43 |
| ▸ | NPY5R | Q15761 | 3/20 | 0.43 |
| ▸ | ACHE | P22303 | 3/20 | 0.35 |
| ▸ | BACE1 | P56817 | 2/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.34 |
| ▸ | HTR2B | P41595 | 2/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.32 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.32 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6457840 | 1.00 | MCHR1 (0.43) | MCHR1ADRA2ANPY5RACHEBACE1 | |
| SCHEMBL6878378 | 0.92 | MCHR1 (0.43) | MCHR1ADRA2ANPY5RACHEBACE1 | |
| SCHEMBL6467603 | 0.92 | MCHR1 (0.43) | MCHR1ADRA2ANPY5RACHEBACE1 | |
| SCHEMBL6460406 | 0.87 | MCHR1 (0.46) | MCHR1ADRA2ANPY5RACHEBACE1 | |
| SCHEMBL6460395 | 0.87 | MCHR1 (0.46) | MCHR1ADRA2ANPY5RACHEBACE1 | |
| SCHEMBL6464914 | 0.86 | MCHR1 (0.49) | MCHR1ADRA2ANPY5RACHEBACE1 | |
| SCHEMBL6880166 | 0.86 | MCHR1 (0.49) | MCHR1ADRA2ANPY5RACHEBACE1 | |
| SCHEMBL6874350 | 0.85 | MCHR1 (0.44) | MCHR1ADRA2ANPY5RACHEBACE1 | |
| SCHEMBL6874340 | 0.85 | MCHR1 (0.44) | MCHR1ADRA2ANPY5RACHEBACE1 | |
| SCHEMBL6460055 | 0.85 | MCHR1 (0.44) | MCHR1ADRA2ANPY5RACHEBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |