Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX12 | P18054 | 2/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 11/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 9/20 | 0.38 |
| ▸ | HRH1 | P35367 | 4/20 | 0.38 |
| ▸ | HTR2B | P41595 | 4/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.36 |
| ▸ | APBA1 | Q02410 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6880766 | 1.00 | ALOX12 (0.44) | ALOX12MCHR1ADRA2AHRH1HTR2B | |
| SCHEMBL6873520 | 0.95 | ALOX12 (0.39) | ALOX12MCHR1ADRA2AHRH1HTR2B | |
| SCHEMBL6880536 | 0.92 | ALOX12 (0.53) | ALOX12MCHR1ADRA2AHRH1HTR2B | |
| SCHEMBL6880533 | 0.92 | ALOX12 (0.53) | ALOX12MCHR1ADRA2AHRH1HTR2B | |
| SCHEMBL6878090 | 0.90 | MCHR1 (0.36) | ALOX12MCHR1ADRA2AHRH1HTR2B | |
| SCHEMBL6878093 | 0.90 | MCHR1 (0.36) | ALOX12MCHR1ADRA2AHRH1HTR2B | |
| SCHEMBL6464453 | 0.90 | EPHX1 (0.44) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6464449 | 0.90 | EPHX1 (0.44) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6869391 | 0.88 | GLA (0.46) | ALOX12MCHR1ADRA2AHRH1HTR2B | |
| SCHEMBL6869396 | 0.88 | GLA (0.46) | ALOX12MCHR1ADRA2AHRH1HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |