Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 18/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | PDE1A | P54750 | 7/20 | 0.40 |
| ▸ | PDE1B | Q01064 | 7/20 | 0.40 |
| ▸ | PDE1C | Q14123 | 7/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6876782 | 0.91 | PDE5A (0.42) | PDE5AKDM4EPDE1APDE1BPDE1C | |
| SCHEMBL6878139 | 0.85 | PDE5A (0.47) | PDE5AKDM4EPDE1APDE1BPDE1C | |
| SCHEMBL6880557 | 0.81 | TSHR (0.44) | PDE5AKDM4ETSHRMAPK1PDE1A | |
| SCHEMBL6878807 | 0.78 | HDAC1 (0.36) | PDE5AKDM4EPDE1APDE1BPDE1C | |
| SCHEMBL6878364 | 0.78 | PDE5A (0.45) | PDE5AKDM4ETSHRMAPK1PDE1A | |
| SCHEMBL6880659 | 0.76 | PDE5A (0.47) | PDE5AKDM4EPDE1APDE1BPDE1C | |
| SCHEMBL6878810 | 0.76 | PDE5A (0.39) | PDE5AKDM4EPDE1APDE1BPDE1C | |
| SCHEMBL1758918 | 0.74 | PDE5A (0.44) | PDE5AKDM4EPDE1APDE1BPDE1C | |
| SCHEMBL6880652 | 0.72 | PDE5A (0.47) | PDE5AKDM4ETSHRMAPK1PDE1A | |
| SCHEMBL1758713 | 0.72 | PDE5A (0.54) | PDE5AKDM4EPDE1APDE1BPDE1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011058582-A1 | HISTONE DEACETYLASE INHIBITORS FOR THE TREATMENT OF FUNGAL INFECTIONS | ORCHID RESEARCH LABORATORIES LTD. (IN) | 2011-05-19 | — | — | WO | disclosed |