Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.44 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | KDM4A | O75164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8690783 | 0.74 | TDP1 (1.00) | TDP1ALDH1A1MAPK1POLBAPEX1 | |
| SCHEMBL16742094 | 0.71 | TDP1 (0.66) | TDP1ALDH1A1SRD5A2SRD5A1MAPK1 | |
| SCHEMBL16742113 | 0.71 | TDP1 (0.66) | TDP1ALDH1A1SRD5A2SRD5A1MAPK1 | |
| SCHEMBL7627993 | 0.69 | TDP1 (0.52) | TDP1ALDH1A1 | |
| SCHEMBL30036421 | 0.69 | TDP1 (0.59) | TDP1ALDH1A1SRD5A2SRD5A1MAPK1 | |
| SCHEMBL19437365 | 0.69 | TDP1 (0.62) | TDP1ALDH1A1MAPK1POLBAPEX1 | |
| SCHEMBL7795998 | 0.69 | TDP1 (0.58) | TDP1ALDH1A1MAPK1POLBAPEX1 | |
| SCHEMBL7795997 | 0.69 | TDP1 (0.62) | TDP1ALDH1A1SRD5A2SRD5A1MAPK1 | |
| SCHEMBL6621488 | 0.68 | SRD5A2 (0.58) | TDP1ALDH1A1SRD5A2SRD5A1MAPK1 | |
| SCHEMBL29429630 | 0.68 | SRD5A2 (0.58) | TDP1ALDH1A1SRD5A2SRD5A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1373191-A1 | ACYLATED INDANYL AMINES AND THEIR USE AS PHARMACEUTICALS | Aventis Pharma Deutschland GmbH (DE) | 2004-01-02 | — | — | EP | disclosed |
| WO-2002064545-A1 | ACYLATED INDANYL AMINES AND THEIR USE AS PHARMACEUTICALS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2002-08-22 | — | — | WO | disclosed |