Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6851761 | 0.84 | KDM4E (0.55) | HDAC1KDM4ENPC1GLAMAPT | |
| SCHEMBL3900804 | 0.77 | HDAC1 (0.41) | HDAC1KDM4ENPC1GLAMAPT | |
| SCHEMBL6854124 | 0.77 | HDAC3 (0.41) | HDAC1KDM4EMAPT | |
| SCHEMBL6852026 | 0.76 | KDM4E (0.33) | KDM4ENPC1GLAMAPTRAB9A | |
| SCHEMBL6847768 | 0.76 | CYP2A6 (0.56) | HDAC1 | |
| SCHEMBL6850474 | 0.76 | HSP90AA1 (0.32) | KDM4ENPC1GLAMAPTRAB9A | |
| SCHEMBL3904118 | 0.73 | HDAC1 (0.38) | HDAC1KDM4ENPC1GLAMAPT | |
| SCHEMBL6854322 | 0.73 | HDAC1 (0.41) | HDAC1KDM4ENPC1GLAMAPT | |
| SCHEMBL6852255 | 0.72 | CYP2A6 (0.37) | — | |
| SCHEMBL13722910 | 0.70 | HDAC1 (0.36) | HDAC1KDM4ENPC1GLAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1585775-A | 6-O-acyl ketolide derivatives of erythromycine useful as antibacterials | ORTHO MCNEIL PHARM INC (US) | 2005-02-23 | — | — | CN | disclosed |
| US-6825170-B2 | ERYTHROMYCIN TYPE MACROLIDE WITH A FUSED OXAZOLONE RING | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2004-11-30 | — | — | US | disclosed |
| EP-1453847-A1 | 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS | Ortho-Mcneil Pharmaceutical, Inc. (US) | 2004-09-08 | — | — | EP | disclosed |
| WO-2003050132-A1 | 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2003-06-19 | — | — | WO | disclosed |