Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 1/20 | 0.39 |
| ▸ | NISCH | Q9Y2I1 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6878393 | 0.88 | — | — | |
| SCHEMBL3281643 | 0.76 | — | — | |
| SCHEMBL8144755 | 0.69 | NOS3 (0.40) | NOS3NOS1NOS2NISCHGAA | |
| SCHEMBL12562500 | 0.69 | NOS3 (0.40) | NOS3NOS1NOS2NISCHGAA | |
| SCHEMBL18651774 | 0.69 | NOS3 (0.40) | NOS3NOS1NOS2NISCHGAA | |
| SCHEMBL9387938 | 0.66 | — | — | |
| SCHEMBL3469069 | 0.64 | TAAR1 (0.34) | NISCHADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL9724806 | 0.62 | NOS3 (0.41) | NOS3NOS1NOS2NISCHGAA | |
| SCHEMBL171997 | 0.61 | — | — | |
| SCHEMBL3281539 | 0.61 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011094285-A1 | COMPOSITIONS AND METHODS FOR TREATING, REDUCING, AMELIORATING, ALLEVIATING, OR INHIBITING PROGRESSION OF, PATHOGENIC OCULAR NEOVASCULARIZATION | BAUSCH & LOMB INCORPORATED (US) | 2011-08-04 | — | — | WO | disclosed |