Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | HTR2B | P41595 | 1/20 | 0.49 |
| ▸ | MALT1 | Q9UDY8 | 7/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6880940 | 1.00 | IGF1R (0.51) | IGF1RHTR2CHTR2BMALT1MAPT | |
| SCHEMBL6880545 | 0.92 | MAPT (0.54) | IGF1RMAPTNPSR1ADRA2AMCHR1 | |
| SCHEMBL6880550 | 0.92 | MAPT (0.54) | IGF1RMAPTNPSR1ADRA2AMCHR1 | |
| SCHEMBL6461805 | 0.89 | IGF1R (0.54) | IGF1RMAPTLMNAADRA2AMCHR1 | |
| SCHEMBL6461800 | 0.89 | IGF1R (0.54) | IGF1RMAPTLMNAADRA2AMCHR1 | |
| SCHEMBL6467397 | 0.87 | MAPT (0.45) | MAPTLMNANPSR1ADRA2AMCHR1 | |
| SCHEMBL6467407 | 0.87 | MAPT (0.45) | MAPTLMNANPSR1ADRA2AMCHR1 | |
| SCHEMBL6874813 | 0.87 | MAPT (0.47) | MAPTNPSR1ADRA2AMCHR1NPC1 | |
| SCHEMBL6874819 | 0.87 | MAPT (0.47) | MAPTNPSR1ADRA2AMCHR1NPC1 | |
| SCHEMBL5522072 | 0.85 | MCHR1 (0.61) | IGF1RHTR2CHTR2BMALT1ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |