Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.44 |
| ▸ | KDR | P35968 | 2/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6880545 | 1.00 | MAPT (0.54) | MAPTSMN1; SMN2NPSR1NPC1MCHR1 | |
| SCHEMBL6874813 | 0.93 | MAPT (0.47) | MAPTSMN1; SMN2NPSR1NPC1MCHR1 | |
| SCHEMBL6874819 | 0.93 | MAPT (0.47) | MAPTSMN1; SMN2NPSR1NPC1MCHR1 | |
| SCHEMBL6880940 | 0.92 | IGF1R (0.51) | MAPTSMN1; SMN2NPSR1NPC1MCHR1 | |
| SCHEMBL6880945 | 0.92 | IGF1R (0.51) | MAPTSMN1; SMN2NPSR1NPC1MCHR1 | |
| SCHEMBL6467397 | 0.91 | MAPT (0.45) | MAPTSMN1; SMN2NPSR1MCHR1KDR | |
| SCHEMBL6467407 | 0.91 | MAPT (0.45) | MAPTSMN1; SMN2NPSR1MCHR1KDR | |
| SCHEMBL6874644 | 0.89 | MAPT (0.49) | MAPTSMN1; SMN2MCHR1ADRA2APOLB | |
| SCHEMBL6874633 | 0.89 | MAPT (0.49) | MAPTSMN1; SMN2MCHR1ADRA2APOLB | |
| SCHEMBL6877589 | 0.85 | EPHX1 (0.53) | MAPTMCHR1KDRADRA2APDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |