Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL38660463 | 1.00 | ELANE (0.50) | ELANESMN1; SMN2NPC1RAB9AHTR2C | |
| SCHEMBL6882618 | 1.00 | ELANE (0.50) | ELANESMN1; SMN2NPC1RAB9AHTR2C | |
| SCHEMBL883433 | 0.89 | NPC1 (0.51) | SMN1; SMN2NPC1RAB9AHTR2C | |
| SCHEMBL30591386 | 0.89 | NPC1 (0.51) | SMN1; SMN2NPC1RAB9AHTR2C | |
| SCHEMBL116516 | 0.89 | NPC1 (0.51) | SMN1; SMN2NPC1RAB9AHTR2C | |
| SCHEMBL883439 | 0.89 | NPC1 (0.51) | SMN1; SMN2NPC1RAB9AHTR2C | |
| SCHEMBL19083887 | 0.89 | NPC1 (0.51) | SMN1; SMN2NPC1RAB9AHTR2C | |
| SCHEMBL29302842 | 0.87 | SMN1; SMN2 (0.56) | SMN1; SMN2NPC1RAB9AHTR2CCYP2C19 | |
| SCHEMBL29302825 | 0.87 | SMN1; SMN2 (0.56) | SMN1; SMN2NPC1RAB9AHTR2CCYP2C19 | |
| SCHEMBL5740609 | 0.87 | SMN1; SMN2 (0.56) | SMN1; SMN2NPC1RAB9AHTR2CCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011091407-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLP (US) | 2011-07-28 | — | — | WO | disclosed |