Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | PREP | P48147 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL116516 | 1.00 | NPC1 (0.51) | NPC1RAB9ASMN1; SMN2FKBP1ANPSR1 | |
| SCHEMBL19083887 | 1.00 | NPC1 (0.51) | NPC1RAB9ASMN1; SMN2FKBP1ANPSR1 | |
| SCHEMBL883439 | 1.00 | NPC1 (0.51) | NPC1RAB9ASMN1; SMN2FKBP1ANPSR1 | |
| SCHEMBL30591386 | 1.00 | NPC1 (0.51) | NPC1RAB9ASMN1; SMN2FKBP1ANPSR1 | |
| SCHEMBL2737913 | 0.93 | PREP (0.54) | FKBP1ANPSR1PREP | |
| SCHEMBL6882618 | 0.89 | ELANE (0.50) | NPC1RAB9ASMN1; SMN2HTR2C | |
| SCHEMBL6881174 | 0.89 | ELANE (0.50) | NPC1RAB9ASMN1; SMN2HTR2C | |
| SCHEMBL38660463 | 0.89 | ELANE (0.50) | NPC1RAB9ASMN1; SMN2HTR2C | |
| SCHEMBL23270785 | 0.89 | SMN1; SMN2 (0.52) | NPC1RAB9ASMN1; SMN2FKBP1ANPSR1 | |
| SCHEMBL16142834 | 0.89 | SMN1; SMN2 (0.52) | NPC1RAB9ASMN1; SMN2FKBP1ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240228488-A1 | HETEROARYL INHIBITORS OF PLASMA KALLIKREIN | TAKEDA PHARMACEUTICALS CO (JP) | 2024-07-11 | — | — | US | disclosed |
| WO-2012040242-A1 | SUBSTITUTED PROLINE INHIBITORS OF HEPATITIS C VIRUS REPLICATION | INTERMUNE, INC. (US) | 2012-03-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240228488-A1 | HETEROARYL INHIBITORS OF PLASMA KALLIKREIN | KLKB1, KLK5, KLK1 | NPC1 410/4885RAB9A 2793/4885SMN1; SMN2 4823/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.