Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER3 | P43115 | 4/20 | 0.43 |
| ▸ | CTSA | P10619 | 7/20 | 0.41 |
| ▸ | ITGB1 | P05556 | 3/20 | 0.40 |
| ▸ | ITGA4 | P13612 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL688669 | 0.92 | PTGER3 (0.42) | PTGER3CTSAITGB1ITGA4MAPT | |
| SCHEMBL688474 | 0.92 | PTGER3 (0.39) | PTGER3CTSAITGB1ITGA4 | |
| SCHEMBL687228 | 0.90 | GNRHR (0.39) | PTGER3CTSAITGB1ITGA4 | |
| SCHEMBL686799 | 0.89 | PTGER3 (0.51) | PTGER3CTSAMAPT | |
| SCHEMBL688233 | 0.88 | PTGER3 (0.43) | PTGER3CTSAMAPTP2RX7 | |
| SCHEMBL688379 | 0.88 | PTGER3 (0.42) | PTGER3CTSA | |
| SCHEMBL688343 | 0.88 | PTGER3 (0.43) | PTGER3CTSAMAPTP2RX7 | |
| SCHEMBL687991 | 0.88 | GNRHR (0.38) | PTGER3CTSAITGB1ITGA4 | |
| SCHEMBL687527 | 0.88 | ITGB1 (0.42) | PTGER3CTSAITGB1ITGA4MAPT | |
| SCHEMBL688878 | 0.88 | PTGER3 (0.41) | PTGER3CTSA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1203766-B1 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS INC (US) | 2012-02-29 | — | — | EP | disclosed |
| EP-1203766-A2 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2002-05-08 | — | — | EP | disclosed |