Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER3 | P43115 | 6/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.38 |
| ▸ | CTSA | P10619 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL688343 | 0.94 | PTGER3 (0.43) | PTGER3MAPTP2RX7POLBTP53 | |
| SCHEMBL687624 | 0.93 | PTGER3 (0.42) | PTGER3MAPTP2RX7POLBTP53 | |
| SCHEMBL688170 | 0.91 | PTGER3 (0.41) | PTGER3MAPTTP53RXFP1SMN1; SMN2 | |
| SCHEMBL687082 | 0.90 | POLB (0.39) | POLBPDE7ACTSASMN1; SMN2CYP26A1 | |
| SCHEMBL688604 | 0.90 | POLB (0.41) | PTGER3POLBPDE7ACTSASMN1; SMN2 | |
| SCHEMBL686799 | 0.90 | PTGER3 (0.51) | PTGER3MAPTPOLBCTSASMN1; SMN2 | |
| SCHEMBL686842 | 0.90 | PTGER3 (0.45) | PTGER3MAPTTP53RXFP1CTSA | |
| SCHEMBL686938 | 0.89 | PTGER3 (0.47) | PTGER3P2RX7RXFP1CTSACYP26A1 | |
| SCHEMBL687242 | 0.89 | SMN1; SMN2 (0.44) | PTGER3MAPTPOLBSMN1; SMN2CNR2 | |
| SCHEMBL688250 | 0.89 | PTGER3 (0.45) | PTGER3MAPTPOLBTP53RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1203766-B1 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS INC (US) | 2012-02-29 | — | — | EP | disclosed |
| EP-1203766-A2 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2002-05-08 | — | — | EP | disclosed |