Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 4/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CCR1 | P32246 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.36 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.36 |
| ▸ | ITGAL | P20701 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 3/20 | 0.36 |
| ▸ | HTR2C | P28335 | 3/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.34 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1604972 | 0.91 | ELANE (0.73) | ELANENPSR1KDM4E | |
| Iodide SCHEMBL1603664 | 0.91 | ELANE (0.72) | ELANE | |
| SCHEMBL1604115 | 0.89 | ELANE (0.72) | ELANENPSR1KDM4E | |
| Acetic Acid SCHEMBL1603917 | 0.87 | ELANE (0.69) | ELANECCR1 | |
| SCHEMBL1604046 | 0.87 | ELANE (0.75) | ELANENPSR1KDM4ECCR1MEN1 | |
| SCHEMBL6882229 | 0.86 | ELANE (0.65) | ELANENPSR1KDM4ECCR1MEN1 | |
| Acetic Acid SCHEMBL1604007 | 0.85 | ELANE (0.72) | ELANENPSR1KDM4ECCR1 | |
| SCHEMBL8219783 | 0.84 | ELANE (0.66) | ELANENPSR1KDM4ECCR1MEN1 | |
| SCHEMBL14922185 | 0.80 | ELANE (0.81) | ELANENPSR1KDM4ECCR1MEN1 | |
| SCHEMBL1604014 | 0.80 | ELANE (0.74) | ELANEHTR2AHTR2CSLC6A4ITGB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011039528-A1 | 2-PYRIDONE COMPOUNDS USED AS INHIBITORS OF NEUTROPHIL ELASTASE | ASTRAZENECA AB (SE) | 2011-04-07 | — | — | WO | disclosed |