Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNNI3K | Q59H18 | 16/20 | 0.49 |
| ▸ | BRAF | P15056 | 14/20 | 0.49 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6881218 | 0.88 | TNNI3K (0.55) | TNNI3KBRAFMKNK1EGFR | |
| SCHEMBL6881665 | 0.86 | TNNI3K (0.56) | TNNI3KBRAFEGFR | |
| SCHEMBL6881214 | 0.83 | TNNI3K (0.51) | TNNI3KBRAFMKNK1EGFR | |
| SCHEMBL16699856 | 0.80 | MKNK1 (0.59) | TNNI3KBRAFMKNK1EGFR | |
| SCHEMBL16699853 | 0.80 | MKNK1 (0.59) | TNNI3KBRAFMKNK1EGFR | |
| SCHEMBL6882264 | 0.76 | EGFR (0.69) | TNNI3KBRAFEGFR | |
| SCHEMBL16705862 | 0.74 | MKNK1 (0.58) | TNNI3KBRAFMKNK1EGFR | |
| SCHEMBL16699899 | 0.74 | MKNK1 (0.58) | TNNI3KBRAFMKNK1EGFR | |
| SCHEMBL16699897 | 0.74 | MKNK1 (0.58) | TNNI3KBRAFMKNK1EGFR | |
| SCHEMBL6883075 | 0.74 | TNNI3K (0.62) | TNNI3KBRAFEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011056739-A1 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2011-05-12 | — | — | WO | disclosed |