Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.40 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PADI4 | Q9UM07 | 2/20 | 0.37 |
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
| ▸ | CHUK | O15111 | 1/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2680869 | 0.78 | PDE2A (0.57) | PDE2AALDH1A1MAPTTSHRCASP7 | |
| SCHEMBL936269 | 0.75 | HDAC1 (0.50) | PDE2AALDH1A1MAPTTSHRCASP7 | |
| SCHEMBL6883842 | 0.74 | PDE2A (0.61) | PDE2AGRIN2DGRIN2AGRIN2BGRIN2C | |
| SCHEMBL936355 | 0.73 | PDE2A (0.57) | PDE2AALDH1A1MAPTTSHRCASP7 | |
| SCHEMBL15648185 | 0.66 | KDM4E (0.70) | ALDH1A1MAPTTSHRCASP7HSD17B10 | |
| SCHEMBL24095578 | 0.66 | MEN1 (0.59) | ALDH1A1MAPTTSHRCASP7HSD17B10 | |
| SCHEMBL31384364 | 0.66 | ALDH1A1 (0.63) | ALDH1A1MAPTTSHRCASP7HSD17B10 | |
| SCHEMBL25849925 | 0.64 | MEN1 (0.63) | ALDH1A1MAPTTSHRCASP7HSD17B10 | |
| SCHEMBL935454 | 0.64 | PDE2A (0.80) | PDE2AGRIN2DGRIN2AGRIN2BGRIN2C | |
| SCHEMBL962565 | 0.62 | PDE2A (0.77) | PDE2AALDH1A1MAPTTSHRCASP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011011312-A1 | QUINOLINONE PDE2 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-01-27 | — | — | WO | disclosed |