Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 2/20 | 0.37 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.37 |
| ▸ | SHBG | P04278 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6758029 | 1.00 | TRPA1 (0.37) | TRPA1TRPM8SHBGROCK2ROCK1 | |
| SCHEMBL6757991 | 1.00 | TRPA1 (0.37) | TRPA1TRPM8SHBGROCK2ROCK1 | |
| SCHEMBL7745825 | 0.88 | TRPA1 (0.39) | TRPA1TRPM8SHBG | |
| SCHEMBL7745828 | 0.88 | TRPA1 (0.39) | TRPA1TRPM8SHBG | |
| SCHEMBL10297543 | 0.88 | TRPA1 (0.39) | TRPA1TRPM8SHBG | |
| SCHEMBL6757777 | 0.84 | CA1 (0.46) | TRPA1TRPM8SHBG | |
| SCHEMBL6757780 | 0.84 | CA1 (0.46) | TRPA1TRPM8SHBG | |
| SCHEMBL6757779 | 0.84 | CA1 (0.46) | TRPA1TRPM8SHBG | |
| SCHEMBL6757782 | 0.84 | CA1 (0.46) | TRPA1TRPM8SHBG | |
| SCHEMBL15369688 | 0.84 | CA1 (0.46) | TRPA1TRPM8SHBG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110112052-A1 | SPIRO-OXINDOLE MDM2 ANTAGONISTS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2011-05-12 | — | — | US | disclosed |
| US-20110009578-A1 | Use Of A Combination Chain Transfer And Activating Agent To Control Molecular Weight And Optical Density Of Pd Catalyzed Norbornene Polymers | PROMERUS LLC (US) | 2011-01-13 | — | — | US | disclosed |
| US-7442800-B2 | Nucleophilic heterocyclic carbene derivatives of Pd(acac)2 for cross-coupling reactions | PROMERUS LLC (US) | 2008-10-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110112052-A1 | SPIRO-OXINDOLE MDM2 ANTAGONISTS | TP53, MDM2, TP53BP1 | TRPA1 2963/4885TRPM8 3497/4885SHBG 1939/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.