Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | RAD52 | P43351 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KDM6B | O15054 | 1/20 | 0.35 |
| ▸ | KDM4A | O75164 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | EP300 | Q09472 | 1/20 | 0.34 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.34 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.34 |
| ▸ | CCNC | P24863 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6881782 | 0.84 | KDM4E (0.49) | AXLKDM4EHTTALDH1A1TDP1 | |
| Hydrochloric Acid SCHEMBL1982096 | 0.82 | KDM4E (0.47) | AXLKDM4EHTTPOLBALDH1A1 | |
| SCHEMBL2222206 | 0.79 | KDM4E (0.54) | AXLKDM4EHTTPOLBALDH1A1 | |
| Bromide SCHEMBL1980504 | 0.78 | KDM4E (0.52) | AXLKDM4EHTTPOLBALDH1A1 | |
| SCHEMBL4020645 | 0.74 | AXL (0.53) | AXLKDM4EHTTPOLBRAD52 | |
| SCHEMBL6880456 | 0.73 | KMT2A (0.50) | KDM4EHTTALDH1A1MEN1MAPT | |
| SCHEMBL6881810 | 0.71 | TDO2 (0.50) | TDO2 | |
| SCHEMBL4021511 | 0.66 | AXL (0.85) | AXLKDM4EHTTPOLBRAD52 | |
| SCHEMBL15887296 | 0.64 | KDM4E (0.46) | AXLKDM4EHTTPOLBALDH1A1 | |
| SCHEMBL16755955 | 0.64 | AXL (0.50) | AXLKDM4EHTTPOLBRAD52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075371-A1 | PYRIDOQUINAZOLINONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME CORP. (US) | 2011-06-23 | — | — | WO | disclosed |