Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | NAMPT | P43490 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | CTSK | P43235 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28649152 | 0.72 | HSD17B10 (0.36) | MEN1KMT2ANR1H2CHRM2CHRM1 | |
| SCHEMBL19056599 | 0.72 | MEN1 (0.51) | MEN1KMT2ANR1H2NAMPT | |
| SCHEMBL22820871 | 0.70 | USP2 (0.36) | NR1H2CHRM2CHRM1CHRM3HSD17B10 | |
| SCHEMBL19025754 | 0.69 | MEN1 (0.45) | MEN1KMT2ANR1H2NAMPT | |
| SCHEMBL6638286 | 0.69 | NR1H2 (0.35) | MEN1KMT2ANR1H2CHRM2CHRM1 | |
| SCHEMBL12248083 | 0.68 | CHRM2 (0.35) | MEN1KMT2ANR1H2CHRM2CHRM1 | |
| SCHEMBL30911168 | 0.68 | MEN1 (0.39) | MEN1KMT2ANR1H2CHRM2CHRM1 | |
| SCHEMBL30872413 | 0.68 | MEN1 (0.39) | MEN1KMT2ANR1H2CHRM2CHRM1 | |
| SCHEMBL8246615 | 0.68 | NR1H2 (0.39) | MEN1KMT2ANR1H2CHRM2CHRM1 | |
| SCHEMBL1630475 | 0.67 | HTT (0.43) | CHRM2CHRM1CHRM3HSD17B10CTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011091407-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLP (US) | 2011-07-28 | — | — | WO | disclosed |