SCHEMBL6884449

SCHEMBL6884449

CCCC(C)c1cccc(O)c1N

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.48
GABRA1 P14867 3/20 0.39
GABRB2 P47870 2/20 0.39
HDAC4 P56524 1/20 0.37
HDAC2 Q92769 1/20 0.37
HDAC8 Q9BY41 1/20 0.37
HPGD P15428 2/20 0.36
HIF1A Q16665 2/20 0.36
GABRG2 P18507 2/20 0.36
GABRB3 P28472 2/20 0.36
FAAH O00519 1/20 0.36
CA1 P00915 1/20 0.36
CA2 P00918 1/20 0.36
LMNA P02545 1/20 0.36
CYP1A2 P05177 1/20 0.36
CYP3A4 P08684 1/20 0.36
GABRB1 P18505 1/20 0.36
PTGS1 P23219 1/20 0.36
SLC6A2 P23975 1/20 0.36
HTR2C P28335 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11420568 0.87 TSHR (0.38) TSHRGABRA1GABRB2HPGDHIF1A
SCHEMBL27511455 0.85 TSHR (0.68) TSHRGABRA1GABRB2HDAC4HDAC2
SCHEMBL6880632 0.84 TSHR (0.41) TSHRGABRA1GABRB2HDAC4HDAC2
SCHEMBL4955633 0.81 TSHR (0.52) TSHRGABRA1GABRB2HDAC4HDAC2
SCHEMBL352351 0.81 TSHR (0.73) TSHRGABRA1GABRB2HDAC4HDAC2
SCHEMBL676779 0.80 TSHR (0.50) TSHRGABRA1GABRB2HDAC4HDAC2
SCHEMBL10669560 0.80 TSHR (0.33) TSHRGABRA1GABRG2GABRB3SOAT1
SCHEMBL1834375 0.79 GABRA1 (0.54) TSHRGABRA1GABRB2HDAC4HDAC2
SCHEMBL28629753 0.79 TSHR (0.48) TSHRGABRA1GABRB2HDAC4HDAC2
SCHEMBL2493029 0.79 TSHR (0.48) TSHRGABRA1GABRB2HDAC4HDAC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1442009-A1 PRODUCTION OF KETO ACIDS Ciba SC Holding AG (CH) 2004-08-04 EP disclosed
WO-2003037846-A1 PRODUCTION OF KETO ACIDS CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2003-05-08 WO disclosed