Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 7/20 | 0.61 |
| ▸ | MMP3 | P08254 | 1/20 | 0.61 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.61 |
| ▸ | MMP13 | P45452 | 1/20 | 0.61 |
| ▸ | BCL2L2 | Q92843 | 5/20 | 0.61 |
| ▸ | BAD | Q92934 | 5/20 | 0.61 |
| ▸ | BCL2 | P10415 | 4/20 | 0.61 |
| ▸ | ADAMTS5 | Q9UNA0 | 3/20 | 0.59 |
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | CRHBP | P24387 | 2/20 | 0.58 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6886503 | 0.86 | PTPN1 (0.57) | PTPN1BCL2L2BCL2MAPTMEN1 | |
| SCHEMBL6884831 | 0.85 | PTPN1 (0.67) | PTPN1MMP3AKR1B1MMP13BCL2L2 | |
| SCHEMBL6884827 | 0.85 | PTPN1 (0.67) | PTPN1MMP3AKR1B1MMP13BCL2L2 | |
| SCHEMBL6885437 | 0.85 | HPGD (0.54) | PTPN1MMP3AKR1B1MMP13BCL2L2 | |
| SCHEMBL6885434 | 0.85 | HPGD (0.54) | PTPN1MMP3AKR1B1MMP13BCL2L2 | |
| SCHEMBL6887688 | 0.85 | MEN1 (0.57) | PTPN1BCL2L2BADBCL2MAPT | |
| SCHEMBL6886589 | 0.84 | PTPN1 (0.56) | PTPN1BCL2L2BADBCL2MAPT | |
| SCHEMBL6887136 | 0.83 | PTPN1 (0.55) | PTPN1BCL2L2BADBCL2MAPT | |
| SCHEMBL6888396 | 0.82 | MAPT (0.56) | PTPN1BCL2L2BADBCL2MAPT | |
| SCHEMBL6884215 | 0.81 | PTPN1 (0.59) | PTPN1BCL2L2BCL2MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6673816-B1 | Rhodanine carboxylic acid derivatives for the treatment and prevention of metabolic bone disorders | Esswein, Angelika (DE) | 2004-01-06 | — | — | US | disclosed |
| US-20030032813-A1 | Rhodanine carboxylic acid derivatives for the treatment and prevention of metabolic bone disorders | ANGELIKA ESSWEIN, WOLFGANG SCHAEFER, AND KONRAD HONOLD | 2003-02-13 | — | — | US | disclosed |
| EP-1117655-A1 | RHODANINE CARBOXYLIC ACID DERIVATIVES FOR THE TREATMENT AND PREVENTION OF METABOLIC BONE DISORDERS | Esswein, Angelika (DE) | 2001-07-25 | — | — | EP | disclosed |
| WO-2000018747-A1 | RHODANINE CARBOXYLIC ACID DERIVATIVES FOR THE TREATMENT AND PREVENTION OF METABOLIC BONE DISORDERS | ROCHE DIAGNOSTICS GMBH (DE) | 2000-04-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030032813-A1 | Rhodanine carboxylic acid derivatives for the treatment and prevention of metabolic bone disorders | NR1H4, NR1D1, NR1I2 | PTPN1 2479/4885MMP3 3403/4885AKR1B1 417/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.